What are the next ITC topics?

The International Titisee Conferences are organized two years in advance. Here you will find topics, chairs, dates, and if already available, lists of confirmed speakers for the upcoming International Titisee Conferences. 

Chaired by Benjamin L. Ebert (Boston, MA, USA) and Peter Campbell (Hinxton, Cambridge, UK)

Somatic mutations accumulate in all cells as we age – these mutations begin to accumulate from the moment of conception and continue steadily throughout life in all tissues, even post-mitotic cells. There is cell-to-cell, organ-to-organ, person-to-person, and country-to-country variation in mutation rates and signatures, with much of this variability remaining unexplained. By the time we reach 70 years of age, our bodies will carry in the order of 100 quadrillion somatic mutations, generating huge clonal diversity among cells, providing the substrate for selective processes to enhance or suppress the growth of individual somatic clones.

The meeting will cover the characterization of somatic mutations in healthy and diseased tissues, across many organ systems, spanning the age range from fetal development to the elderly. We will consider the roles that somatic mutations play in the earliest stages of cancer evolution, the functional decline associated with advancing age, and the pathogenesis of diseases other than cancer. We will explore how somatic mutations and selective landscapes could be manipulated, initially in experimental models but ultimately in vivo in humans, to modify the pace of ageing and cancer development.

Invited Speakers:

  • Cvejic, Ana (Cambridge, UK)
  • Dick, John (Toronto, ON, Canada)
  • Fernandez-Antoran, David (Cambridge, UK)
  • Garaycoechea, Juan I. (Utrecht, The Netherlands)
  • Gleeson, Joe (La Jolla, CA, USA)
  • Goodell, Margaret (Houston, TX, USA)
  • Graham, Trevor (London, UK)
  • Grayson, Peter (Bethesda, MD, USA)
  • Hård, Joanna (Zurich, Switzerland)
  • Jaiswal, Siddhartha (Stanford, CA, USA)
  • Janes, Sam (London, UK)
  • Jones, Phil H. (Cambridge, UK)
  • Ju, Young Seok (Daejon, Korea)
  • Knappskog, Stian (Bergen, Norway)
  • Kregar, Lori D. (Cambridge, UK)
  • Landau, Dan (New York, NY, USA)
  • López-Bigas, Núria (Barcelona, Spain)
  • Manz, Markus (Zurich, Switzerland)
  • Martincorena, Inigo (Hinxton, Cambridgehire, UK)
  • Maslov, Alex (Bronx, NY, USA)
  • Nangalia, Jyoti (Cambridge, UK)
  • Naxerova, Kamila (Boston, MA, USA)
  • Niemeyer, Charlotte (Freiburg, Germany)
  • Ólafsson, Sigurgeir (Reykjavik, Island)
  • Patel, Ketan J. (Oxford, UK)
  • Poetsch, Anna (Dresden, Germany)
  • Rahbari, Raheleh (Hinxton, Cambridgehire, UK)
  • Sankaran, Vijay (Boston, MA, USA)
  • Stratton, Mike (Hinxton, Cambridgehire, UK)
  • Walsh, Christopher (Boston, MA, USA)
  • Weeks, Lachelle Dawn (Boston, MA, USA)
  • Yates, Lucy (Hinxton, Cambridgehire, UK)
  • Zhu, Hao (Dallas, TX, USA)
  • Zucman-Rossi, Jessica (Paris, France)

Chaired by Maja Schuldiner, Rehovot, Israel and Blanche Schwappach-Pignatoro, Hamburg, Germany

One of the hallmarks of eukaryotic cells are their membrane-bound organelles that create biochemically distinct environments within the cellular milieu. Organelles enable a diversification of functions that is extremely beneficial to the cell. However, it also creates the cell’s most severe problem – how to ensure successful communication between membrane-bound entities to coordinate cellular function.

The 2024 Titisee spring-meeting will showcase the varied ways in which organelles communicate and coordinate – through contact sites, signalling cascades, and vesicular trafficking pathways. We will also focus on how these means of communication are hijacked during infection and on the cellular consequences of their breakdown during ageing and disease progression. Our overarching goal is to bring together experts from multiple disciplines that usually do not meet to uncover fundamental principles of intracellular organization and communication.

Invited speakers

  • Antonny, Bruno (Valbonne, France)
  • Bayer, Emmanuelle (Bordeaux, France)
  • Bohnert, Maria (Münster, Germany)
  • Broichhagen, Johannes (Berlin, Germany)
  • Carvalho, Pedro (Oxford, United Kingdom)
  • Chacinska, Agnieszka (Warsaw, Poland)
  • Costello, Joseph (Exeter, United Kingdom)
  • Cruz-Zaragoza, Luis Daniel (Göttingen, Germany)
  • Firat Karalar, Elif Nur (Istanbul, Turkey)
  • Forester, Alison (Namur, Belgium)
  • Gonzalez Montoro, Ayelen (Osnabrück, Germany)
  • Griffiths, Gillian M. (Cambridge, UK)
  • Hermann, Johannes (Kaiserslautern Germany)
  • Höglinger, Doris (Oxford, United Kingdom)
  • Jabs, Sabrina (Kiel, Germany)
  • Kim, Peter K. (Toronto, ON, Canada)
  • Klemm, Robin W. (Oxford, United Kingdom)
  • Kukulski, Wanda (Bern, Switzerland)
  • Laufmann, Orly (Rehovot, Israel)
  • McDowell, Melanie (Frankfurt/Oder, Germany)
  • Misgeld, Thomas (Munich, Germany)
  • Nuebel, Esther ( Salt Lake City, UT, USA)
  • Padinjat, Raghu (Bangalore, India)
  • Rapaport, Doron (Tübingen, Germany)
  • Reggiori, Fulvio Mario (Aarhus, Denmark)
  • Rehling, Peter (Göttingen, Germany)
  • Sheiner, Liach (Glasgow, United Kingdom)
  • Shpilka, Tomer (Worchester, MA, USA)
  • Sigismund, Sara Lucia Giustina (Milano, Italy)
  • Spang, Anne (Basel, Switzerland)
  • Stenmark, Harald (Oslo, Norway)
  • Voeltz, Gia (Boulder, CO, USA)
  • Walter, Peter (San Francisco, CA, USA)
  • Winklhofer, Konstanze F. (Bochum, Germany)

Chaired by Anthony Hyman, Dresden, Germany and Donald Hilvert, Zurich, Switzerland

More information will follow soon!