What kind of research we fund
What we do and do not fund
The Boehringer Ingelheim Fonds (BIF) supports only experimental projects in basic biomedical research, including in silico projects, aimed at elucidating basic biological phenomena of human life and acquiring new scientific knowledge.
We do not fund
- Applied research, such as biotechnological and pharmaceutical development (e.g. development of assays for diagnostic purposes or drug screening, optimization or screening of substances/compounds for therapeutic use, development of drug delivery systems or vaccines)
- Studies on the course of diseases or the treatment of symptoms
- Botanical and prokaryotic investigations, unless they are of general biological importance
- Education. As we can only support research, fellowships may not be used during the course and rotation phase of PhD programmes, but only for the duration of the PhD research project.
In this project, specific substances will be explored to develop and validate in vitro and in vivo novel non-invasive agents for optical imaging, to monitor cancer progression, and differentiation into different cancer forms. Notably, these probes can be further evaluated for therapeutic applications.
The major challenge of cancer therapy is to achieve specific, efficient, and safe systemic delivery of therapeutic molecules into the tumour microenvironment. This proposal wants to investigate multifunctional nanoparticles as delivery vehicles. The project aims to investigate basic aspects such as nanoparticle size and concentration, cell targeting, and cellular uptake.
Currently, a number of pathways and regulators have been identified that might constitute drug targets for clinical therapy. Among them receptor X is a negative regulator of cell differentiation and the pharmacological modulation of this receptor represents a promising therapeutic approach. To this end, we want to screen compound libraries aiming at the identification of lead substances that can modulate receptor X function.
Novel drugs and drug combinations against disease X are urgently needed. Therefore, I aim to 1. determine the activity of 8 anti-X drugs in an in vitro system, 2. determine the activity of 3 anti-X drug combinations, 3. determine the activity of a new combination of 3 drugs.
Disease course or treatment of symptoms (clinical studies)
The aim of the project is to evaluate whether treatment with substance X improves cognitive function in patients with disease Y. Control subjects will include patients with syndrome AB who are receiving substance X for this condition. The objectives are: To study in patients with disease Y and in control patients the effect of substance X on: 1) cognitive and motor functions, analysed by psychometric tests; 2) the molecular alterations involved in cognitive disorders; 3) the brain abnormalities, analysed by means of fMRI and EEG.
We fund e.g. projects that
- Try to solve the molecular structure and function of cellular proteins using, for example, biochemical, microscopic, or biophysical methods
- Analyse basic cellular, molecular, developmental, or genetic mechanisms, for example, in vitro or in model organisms that might be relevant to the human system
- Try to understand the human brain and those of model organisms, or projects elucidating the multiple functions of the nervous system
- Analyse basic mechanisms of tumour biology
- Try to understand the basic functions and principles of the immune system
- Study basic mechanisms of infection, analysing infectious agents that are relevant to humans
- Use bioinformatics approaches to answer, e.g. any of the above-mentioned problems.
- Mechanisms of cytokinesis in budding yeast
- Live imaging and mathematical modelling of inner nuclear membrane protein targeting reveal its molecular requirements in mammalian cells
Molecular biology and genetics
- In vivo and transcriptome-wide identification of RNA-binding protein target sites
- Monitoring homology search during DNA double-strand break repair in vivo
- RNA polymerase I structure and transcription regulation
- Structural and functional analysis of telomerase
- High-throughput imaging of neuronal activity in Caenorhabditis elegans chemotaxis
- Spontaneous activity in the development of neural circuits
- Balance and stability of synaptic structures during synaptic plasticity
Biological basis of diseases
- IL-33 signalling contributes to the pathogenesis of myeloproliferative neoplasms
- Transcription regulates telomere dynamics in human cancer cells
- Individual intestinal symbionts induce a distinct population of RORgammy+ regulatory T cells
- Heterochromatin protein 1 secures survival and transmission of malaria parasites
- Single-molecule study of the intrinsically disordered FG-repeat nucleoporin 153
If you are not sure whether your project fits within the scope of what we support, you are welcome to contact us.