What were past ITC topics?
From the very first conference in 1962, the International Titisee Conferences (ITCs) were meant to offer a unique experience for the participating scientists. The idea was to create an inviting, retreat-like setting as well as an atmosphere that would stimulate scientific exchange between researchers and between subdisciplines. Until 1983, the ITCs were organized by the Company Dr Karl Thomae GmbH, a subsidiary of Boehringer Ingelheim company. From then on, the newly founded non-profit foundation Boehringer Ingelheim Fonds (BIF) took over their organization and the focus shifted from medicine to basic research in biomedical science. Their concept, however, has changed little over time, and the ITCs have gained an excellent reputation among scientists.
Chaired by Karla Neugebauer (New Haven, CT, USA) and Christine Mayr (New York, NY, USA)
Cellular RNA molecules have exquisitely controlled sequences as well as secondary and tertiary structures. Collectively, they interact with thousands of proteins and can generate higher order structures. They scaffold and target regulatory complexes, catalyze protein synthesis, and determine how nascent proteins assemble into complexes. The majority occupy different subcellular compartments. In spite of their known diversity and functionality, biology continues to place proteins in the driver’s seat. For example, it is thought that proteins bring RNA cargoes to distant corners of the cell when, in fact, some proteins do not even localize to those corners without binding RNA. Also, RNA may drive the properties of local environments necessary for proper protein function. Are biologists overlooking RNA as a major driver for cellular organization and function? The notion that life began in an RNA World implies this. We need to think more creatively about what RNA can and does do for cells, tissues and organisms.
This meeting will address the fundamentals of RNA in cells: the sequences, shapes, activities, concentrations, dynamics, localization patterns, and interaction partners. Participants will be drawn from a diverse community of researchers with knowledge of RNA biology in different kinds of cells and organisms. We will look at cutting-edge methods for analyzing RNA and the emerging data. We will envision new ways of thinking about RNA in cells and discuss what our field needs to elucidate the many roles of RNA in regulating cellular function.
- Akhtar, Asifa (Freiburg, Germany)
- Bevilacqua, Philip (University Park, PA, USA)
- Böke, Elvan (Barcelona, Spain)
- Boothby, Thomas C. (Laramie, WY, USA)
- Brennecke, Julius F. (Vienna, Austria)
- Buchan, Ross (Tuscon, AZ, USA)
- Cech, Thomas R. (Boulder, CO, USA)
- Cuylen-Häring, Sara (Heidelberg, Germany)
- Flynn, Ryan A. (Stanford, CA, USA)
- Fox, Archa (Perth, WA, Australia)
- Gilbert, Wendy (New Haven, CT, USA)
- Gladfelter, Amy (Chapel Hill, CT, USA)
- Gueroui, Zoher (Paris, France)
- Heyd, Florian (Berlin, Germany)
- Hilgers, Valerie (Freiburg, Germany)
- Hondele, Maria (Basel, Switzerland)
- Jaffrey, Samie R. (New York, NY, USA)
- Kudla, Grzegorz (Edinburgh, UK)
- Landthaler, Markus (Berlin, Germany)
- Lehmann, Ruth (New York, NY, USA)
- Lemke, Edward (Mainz, Germany)
- MacRae, Ian J. (La Jolla, CA, USA)
- Nott, Timothy (Oxford, UK)
- Parker, Roy (Boulder, CO, USA)
- Pelkmans, Lucas (Zürich, Switzerland)
- Polymenidou, Madgalini (Zürich, Switzerland)
- Seelig, Georg (Seattle, WA, USA)
- Seydoux, Geraldine (Baltimore, MD, USA)
- Shiber, Ayala (Haifa, Israel)
- Solovei, Irina (Martinsried, Germany)
- Tang, Tsing-Young Dora (Dresden, Germany)
- Trcek, Tatjana (Baltimore, MD, USA)
- Ule, Jerney (London, United Kingdom)
- Weil, Dominique (Paris, France)
Chaired by Tobias Erb (Marburg, Germany) and Marileen Dogterom (Delft, The Netherlands)
For centuries, biology has focused on understanding the fundamental principles of life through an analytical-descriptive approach. However, recent technological developments made it possible to approach life in a synthetic-constructive fashion. Within the last years, we have witnessed the successful extension of the genetic code, the design of novel proteins and cellular scaffolds, the reconstitution of functional cellular modules, as well as the realization of new-to-nature genetic and metabolic networks. Several international consortia have formed that aim at combining these individual elements of life to construct more complex systems that show life-like properties.
At the dawn of this next revolution in life sciences, this meeting aims at bringing together biologists, chemists, physicists, as well as material- and nano-scientists, who focus on (re-)constructing life with synthetic efforts. Together, leading and upcoming scientists in this field of bottom-up synthetic biology will discuss current progress and challenges in the field and develop new collaborative efforts to further advance synthetic biology. We will address scientific, technical, ethical and societal challenges in bottom-up synthetic biology and develop a roadmap towards the ultimate goal of the field, the successful design and realization of synthetic cells.
- Arnold, Francis (Pasadena, CA, USA)
- Blanchoin, Laurent (Grenoble, France)
- Cai, Patrick Yizhi (Manchester, UK)
- Chin, Jason W. (Cambridge, UK)
- Danelon, Christophe (Delft, The Netherlands)
- Elani, Yuval (London, UK)
- Ganzinger, Kristina (Amsterdam, The Netherlands)
- Göpfrich, Kerstin (Heidelberg, Germany)
- Höcker, Birte (Bayreuth, Germany)
- Holliger, Philipp (Cambridge, UK)
- Kerfeld, Cheryl A. (East Lansing, MI, USA)
- Maerkl, Sebastian (Lausanne, Switzerland)
- Meijer, Bert (Eindhoven, The Netherlands)
- Moran, Joseph (Strasbourg, France)
- Niederholtmeyer, Henrike (Marburg, Germany)
- Panke, Sven (Basel, Switzerland)
- Poolman, Bert (Groningen, The Netherlands)
- Rivas Caballero, Germán (Madrid, Spain)
- Samanta, Avik (Mainz, Germany)
- Schweizer, Jakob (Magdeburg, Germany)
- Schwille, Petra (Martinsried, Germany)
- Tang, Dora (Dresden, Germany)
- Wegner, Seraphine V. (Münster, Germany)
Chaired by Leonid Mirny (Cambridge, MA, USA) and Job Dekker (Worcester, MA, USA)
Cells organize their genomes in three-dimensional space to facilitate and regulate a wide array of chromosomal functions ranging from gene regulation and DNA replication to chromosome condensation and segregation during cell division. During the last decade we have witnessed a revolution in our ability to measure the structural organization of chromosomes at increasing resolution and detailed views of the folded state of chromosomes can now be obtained even from single cells. These insights are now leading to new questions about the mechanisms and dynamics of chromosome folding, and the ways chromosome conformation relates to chromosome function.
Addressing these current questions requires highly interdisciplinary approaches at the interface of biology and physics. This includes development and application of experimental systems for structure–function analysis on the one hand, and physical modelling on the other to test and study the mechanisms of folding, the relation to gene regulation and other processes, and the molecular machines involved in these processes.
This inter-disciplinary meeting aims to bring together scientists who study chromosome folding and apply a wide range of approaches including cell biological studies, imaging-based measurements, genomics assays, computational analyses, polymer physics, and dynamic simulations of chromosome folding mechanisms.
- Bienko, Magda (Solna, Sweden)
- Brangwynne, Clifford P. (Princeton, NJ, USA)
- Coulon, Antoine (Paris, France)
- Dekker, Cees (Delft, The Netherlands)
- Earnshaw, William C. (Edinburgh, United Kingdom)
- Gerlich, Daniel (Vienna, Austria)
- Giorgetti, Luca (Basel, Switzerland)
- Gregor, Thomas (Paris, France)
- Grosberg, Alexander Y. (New York, NY, USA)
- Heard, Edith (Heidelberg, Germany)
- Hirano, Tatsuya (Wako, Saitama, Japan)
- Jost, Daniel (Lyon, France)
- Kaplan, Noam (Haifa, Israel)
- Khrameeva, Ekaterina (Moscow, Russia)
- Kleckner, Nancy (Cambridge, MA, USA)
- Marko, John (Evanston, IL, USA)
- Marlow, Heather (Chicago, IL, USA)
- McCord, Rachel Patton (Knoxville, TN, USA)
- Peters, Jan-Michael (Vienna, Austria)
- Rando, Oliver (Worchester, MA, USA)
- Rosa, Angelo (Trieste, Italy)
- Solovei, Irina (Martinsried, Germany)
- Spitz, Francois (Chicago, IL, USA)
- Tachibana, Kikue (Vienna, Austria)
- Zhuang, Xiaowei (Cambridge, MA, USA)
- Zidovska, Alexandra (New York, NY, USA)
Chaired by Thomas Boehm (Freiburg, Germany) and David G. Schatz (New Haven, CT, USA)
Recent findings have called into question the long-held notion of the successive appearance, in evolutionary history, of innate and adaptive responses and their clear-cut functional dichotomy. It is becoming clear that an evolutionarily informed view of immune functions will not only change our perception of the interconnected structure and design of the immune system, but may even lead to non-intuitive strategies for intervention in humans who suffer from immunodeficiency or immune dysregulation.
- Andino, Raul (San Francisco, CA, USA)
- Ayres, Janelle S. (La Jolla, CA, USA)
- Conticello, Silvo (Florence, Italy)
- Cooper, Max D. (Atlanta, GA, USA)
- Cremer, Sylvia (Klosterneuburg, Austria)
- Eberl, Gérard (Paris, France)
- Ewbank, Jonathan (Marseille, France)
- Fischer, Alain (Paris, France)
- Flajnik, Martin F. (Baltimore, MD, USA)
- Fugmann, Sebastian D. (Kwei-Shan, Tao-Yuan, Taiwan)
- Giorgetti, Orlando Bruno (Freiburg, Germany)
- Hagai, Tzachi (Tel Aviv, Israel)
- Hornung, Veit (Munich, Germany)
- Hsu, Ellen (Brooklyn, NY, USA)
- Iyer, Aravind (Bethesda, MD, USA)
- Kaufmann, Jim (Cambridge, United Kingdom)
- Koonin, Eugene V. (Bethesda, MD, USA)
- Levraud, Jean-Pierre (Paris, France)
- Maekawa, Takaki (Köln, Germany)
- Malik, Harmit S. (Seattle, WA, USA)
- Melandri, Daisy (London, UK)
- Nicotra, Matthew L. (Pittsburgh, PA, USA)
- Papavasiliou, Nina (Heidelberg, Germany)
- Ramakrishnan, Lalita (Cambridge, United Kingdom)
- Rosental, Benyamin (Sede Boger, Israel)
- Schmid-Hempel, Paul (Zurich, Switzerland)
- Smith, L. Courtney (Washington, DC, USA)
- Strid, Jessica (London, United Kingdom)
- Valenzano, Dario R. (Cologne, Germany)
- Venkatesh, Byrappa (Singapore, Singapore)
Chaired by Elly Tanaka (Vienna, Austria), Peter Reddien (Cambridge, MA, USA), and James Sharpe (Barcelona, Spain)
Formation of body structures during embryonic development and regeneration share a common endpoint. Yet the starting conditions and scale during which patterning and cell decisions are executed vary enormously. Recently, we have made progress in our molecular understanding of embryonic patterning and regenerative mechanisms along with exciting developments in organoid biology. To discuss these topics, we would like to bring together participants working on patterning dynamics, signal interpretation in multiple developmental and regenerative contexts.
Quantitative modelling is and will be making an important contribution to fuel ideas and provide predictive hypotheses and therefore will constitute a significant part of this meeting. We hope you share our interest in exploring this area in the intimate setting of the 119th International Titisee Conference.
- Aulehla, Alexander (Heidelberg, Germany)
- Barkai, Naama (Rehovot, Israel)
- Birnbaum, Kenneth D. (New York, NY, USA)
- Briscoe, James (London, United Kingdom)
- Coen, Enrico (Norwich, United Kingdom)
- De Simone, Alessandro (Durham, NC, USA)
- Desplan, Claude (New York, NY, USA)
- Eiraku, Mototsugu (Kobe, Japan)
- Gartner, Zev (San Francisco, CA, USA)
- Harris, Matthew (Boston, MA, USA)
- Jülicher, Frank (Dresden, Germany)
- Junker, Jan Philipp (Berlin, Germany)
- Kicheva, Anna (Klosterneuburg, Austria)
- Kondo, Shigeru (Osaka, Japan)
- Li, Pulin (Pasadena, CA, USA)
- Liberali, Prisca (Basel, Switzerland)
- Lobo, Daniel (Baltimore, MD, USA)
- Megason, Sean (Boston, MA, USA)
- Miguez Gómez, David G. (Madrid, Spain)
- Mii, Yusuke (Okazakii, Aichi, Japan)
- Müller, Patrick (Tübingen, Germany)
- Pauli, Andrea (Vienna, Austria)
- Pera, Edgar (Lund, Sweden)
- Plikus, Maksim (Irvine, CA, USA)
- Poss, Kenneth D. (Durham, NC, USA)
- Rawlins, Emma (Cambridge, United Kingdom)
- Rink, Jochen (Dresden, Germany)
- Roy, Sougata (College Park, MD, USA)
- Saunders, Timothy (Singapore, Singapore)
- Schier, Alexander F. (Cambridge, MA, USA)
- Siggia, Eric D. (New York, NY, USA)
- Simons, Benjamin D. (Cambridge, United Kingdom)
- Trivedi, Vikas (Barcelona, Spain)
- van Oudenaarden, Alexander (Utrecht, The Netherlands)
- Whited, Jessica (Boston, MA, USA)
Chaired by Wendy A. Bickmore (Edinburgh, United Kingdom) and Sarah A. Teichmann (Hinxton, Cambridge, United Kingdom)
We have entered an era where we can profile the transcriptome and gene regulatory network of individual cells, and use this information to redefine what we mean by a cell type. This has the potential to provide powerful new insights into developmental biology, physiology and disease etiology. However, most single cell analyses have been applied to cells in suspension - e.g. from the haematopoietic and immune systems and cells have generally been considered as individual self–contained units. By contrast, most cells in the body exist in solid tissues with defined cell–cell contacts, polarities and position within a complex 3D tissue architecture.
This meeting aims to bring together researchers from very diverse communities: those experimentally investigating tissue architecture and gene regulation, those generating ex vivo organoid models of tissues, and computational scientists and mathematicians interested in analysing and modelling these complex datasets. By bringing together these groups of scientists, we will discuss progress towards understanding how different cell types are formed, communicate with each other and work together to form and maintain tissues.
- Adey, Andrew (Portland, OR, USA)
- Barker, Nicholas (Singapore, Singapore)
- Bhatia, Shipra (Edinburgh, United Kingdom)
- Blanpain, Cédric (Bruxelles, Belgium)
- Bodenmiller, Bernd (Zurich, Switzerland)
- Bonev, Boyan (Planegg-Martinsried, Germany)
- Bressan, Dario (Cambridge, United Kingdom)
- Chedotal, Alain (Paris, France)
- de Bruijn, Marella (Oxford, United Kingdom)
- Ezhkova, Elena (New York, NY, USA)
- Grün, Dominic (Freiburg, Germany)
- Haniffa, Muzlifah (Newcastle upon Tyne, United Kingdom)
- Hemberg, Martin (Hinxton, Cambridge, United Kingdom)
- Itzkovitz, Shalev (Rehovot, Israel)
- Jones, Phil H. (Hinxton, Cambridge, United Kingdom)
- Kind, Jop (Utrecht, The Netherlands)
- Kirschner, Marc W. (Boston, MA, USA)
- Lindsay, Susan (Newcastle upon Tyne, United Kingdom)
- Lindskog Bergström, Cecilia (Uppsala, Sweden)
- Lundeberg, Joakim (Solna, Sweden)
- Marioni, John (Hinxton, Cambridge, United Kingdom)
- Ponting, Chris P. (Edinburgh, United Kingdom)
- Reddington, James (Heidelberg, Germany)
- Sauka-Spengler, Tatjana (Oxford, United Kingdom)
- Singer, Meromit (Boston, MA, USA)
- Steel, Karen P. (London, United Kingdom)
- Sudmant, Peter H. (Berkeley, CA, USA)
- Theis, Fabian J. (Neuherberg, Germany)
- Trapnell, Cole (Seattle, WA, USA)
- Vallejos, Catalina (Edinburgh, United Kingdom)
- Villani, Alexandra-Chloé (Cambridge, MA, USA)
- Voet, Thierry (Hinxton, Cambridge, United Kingdom)
Chaired by Melina Schuh (Göttingen, Germany) and Takashi Hiiragi (Heidelberg, Germany)
Understanding the development of mammalian oocytes and embryos is of fundamental importance and direct relevance to reproductive medicine. However, our understanding of this topic is limited. This is largely due to technical limitations that make research on mammalian oocytes and embryos particularly challenging.
Over the past few years, innovative methods have become available that have paved the way for new directions of research in this exciting field. This conference aims to share these technologies and the latest research that has emerged from its use. It will bring together investigators from different fields including cell biology, embryology, biophysics, single-cell biology as well as stem cell biology. The goal is to identify synergies, establish collaborative efforts and generate new ideas for research on mammalian oocytes and embryos.
- Anger, Martin (Brno, Czech Republic)
- Bedzhov, Ivan (Münster, Germany)
- Conti, Marco (San Francisco, CA, USA)
- Elder, Kay (Cambridge, UK)
- Ellenberg, Jan (Heidelberg, Germany)
- Fitzharris, Greg (Montreal, QB, Canada)
- Günesdogan, Ufuk (Göttingen, Germany)
- Herbert, Mary (Newcastle upon Tyne, United Kingdom)
- Hoffmann, Eva R. (Copenhagen, Denmark)
- Höög, Christer (Stockholm, Sweden)
- Sevan Hopyan (Toronto, ON, Canada)
- Hufnagel, Lars (Heidelberg, Germany)
- Jaffe, Laurinda (Farmington, CT, USA)
- Jessberger, Rolf (Dresden, Germany)
- Kitajima, Tomoya S. (Kobe, Japan)
- Lampson, Michael ( Philadelphia, PA, USA)
- Lanner, Fredrik (Stockholm, Sweden)
- Lei, Lei (Ann Arbor, MI, USA)
- Madgwick, Suzanne (Newcastle upon Tyne, United Kingdom)
- Maître, Jean-Léon (Paris, France)
- Sophie Morgani (New York, NY, USA)
- Niakan, Kathy (London, United Kingdom)
- Plachta, Nicolas (Proteos, Singapore)
- Robson, Paul (Farmington, CT, USA)
- Rodriguez, Tristan (London, United Kingdom)
- Rossant, Janet (Toronto, ON, Canada)
- Saitou, Mitinori (Kyoto, Japan)
- Sasaki, Hiroshi (Suita, Osaka, Japan)
- Schatten, Gerald P. (Pittsburg, PA, USA)
- Šolc, Petr (Libechov, Czech Republic)
- Srinivas, Shankar (Oxford, United Kingdom)
- Terret, Marie-Emilie (Paris, France)
- Torres-Padilla, Maria Elena (München, Germany)
- Tóth, Attila (Dresden, Germany)
- Verlhac, Marie-Helene (Paris, France)
- Wassmann, Katja (Paris, France)
- Zachariae, Wolfgang (Martinsried, Germany)
- Zernicka-Goetz, Magdalena (Cambridge, United Kingdom)
Chaired by Roy Kishony (Haifa, Israel) and David A. Relman (Stanford, CA, USA)
Microbial species live and evolve within multi-species consortia that play critical roles in ecology and in human health and disease. These multi-species microbial communities are dynamic, continuously responding, adapting, and evolving in response to external stimuli and stresses. Antibiotics in particular strongly modulate microbes and their communities across multiple levels, from physiology to species composition to evolution over astonishingly rapid timescales. Recent advances in the theory of microbial communities, together with new genomic and metagenomic experimental approaches, are now generating new fundamental insights into how these multi-level microbial community dynamics combine to determine overall community function and adaptability. They have begun to allow predictive quantitative analyses and manipulations of microbial consortia, with far-reaching implications for environmental challenges and management of health and disease.
This conference will bring together scientists from diverse fields, including synthetic biologists building multi-species communities, evolutionary biologists exploring the micro-evolution of individual species, and ecologists and computational biologists analyzing the dynamics of multi-species communities. By bringing these groups together, this meeting seeks to identify new opportunities for major advances, and generate synergistic interactions between fields and investigators. In this way, we anticipate that this meeting will help to expand a growing new interdisciplinary field at the intersection of microbiology, systems and synthetic biology, evolution, and pharmacology.
- Belkaid, Yasmine (Bethesda, MD, USA)
- Borenstein, Elhanan (Seattle, WA, USA)
- Bork, Peer (Heidelberg, Germany)
- Comstock, Laurie Elizabeth (Boston, MA, USA)
- Dagan, Tal (Kiel, Germany)
- Desai, Michael M. (Cambridge, MA, USA)
- Eldar, Avigdor (Tel Aviv, Israel)
- Elinav, Erin (Rehovot, Israel)
- Falter-Braun, Pascal (Neuherberg, Germany)
- Foster, Kevin (Oxford, United Kingdom)
- Friedman, Jonathan (Rehovot, Israel)
- Geva-Zatorsky, Naama (Haifa, Israel)
- Grad, Yonatan (Boston, MA, USA)
- Häußler, Susanne (Braunschweig, Germany)
- Hung, Deborah (Cambridge, MA, USA)
- Ingmer, Hanne (Frederiksberg, Denmark)
- Lenski, Richard E. (East Lansing, MI, USA)
- Lieberman, Tami (Cambridge, MA, USA)
- Lindell, Debbie (Haifa, Israel)
- Mitri, Sara (Lausanne, Switzerland)
- Molin, Søren (Kongens Lyngby, Denmark)
- Pál, Csaba (Szeged, Hungary)
- Parkhill, Julian (Hinxton, United Kingdom)
- Petrov, Dimitri (Stanford, CA, USA)
- Rainey, Paul (Plön, Germany)
- Robert, Lydia (Paris, France)
- Segev, Einat (Rehovot, Israel)
- Segre, Julie (Bethesda, MD, USA)
- Segre, Daniel (Boston, MA, USA)
- Sharon, Itai (Kiryat Shmona, Israel)
- Sher, Daniel (Haifa, Israel)
- Sommer, Morton O.A. (Kongens Lyngby, Denmark)
- Stern, Adi (Tel Aviv, Israel)
- Typas, Nassos (Heidelberg, Germany)
- Vetsigian, Kalin (Madison, WI, USA)
- Yaffe, Eitan (Stanford, CA, USA)
- Yassour, Moran (Cambridge, MA, USA)
Chaired by Vamsi K. Mootha (Boston, MA, USA) and Michael W. Gray (Halifax, NS, Canada)
This International Titisee Conference will focus on mitochondria. Mitochondria were a part of the earliest eukaryotes and, over billions of years, have undergone tremendous lineage-specific evolution, today exhibiting remarkable molecular, biochemical, and metabolic diversity. While animal mitochondria contain a high copy number of their circular genome, other organisms' mitochondrial genomes exhibit a wide array of physical forms, they also differ in their gene arrangements and modes of expression. Still other organisms have lost substantial portions of their mitochondrial genome, including genes encoding parts of the respiratory chain, in extreme cases dispensing with the mitochondrial genome in its entirety. Mitochondria can exhibit variant configurations of the respiratory chain, with alternative electron donors and acceptors, all designed to preserve bioenergetics and promote survival under diverse environmental conditions.
The 115th ITC brings together investigators studying mitochondria from a phylogenetically broad range of eukaryotes, with the goal of exploring the mechanistic basis and physiological consequences of their diversity.
- Afasizhev, Ruslan (Boston, MA, USA)
- Alfonso, Juan (Columbus, OH, USA)
- Balaban, Robert S. (Bethesda, MD, USA)
- Balk, Janneke (Colney, Norwich, United Kingdom)
- Burger, Gertraud (Montreal, QC, Canada)
- Calvo, Sarah (Boston, MA, USA)
- Cardoso Pereira, Inês A. (Oeiras, Portugal)
- Chouchani, Edward T. (Boston, MA, USA)
- Stuart J. Ferguson (Oxford, United Kingdom)
- Gabaldón Estevan, Toni (Barcelona, Spain)
- Gawryluk, Ryan M. (Halifax, NS, Canada)
- Hand, Steven C. (Baton Rouge, LA, USA)
- Harsman, Anke (Bern, Switzerland)
- Huynen, Martijn A. (Nijmegen, The Netherlands)
- Jackman, Jane E. (Columbus, OH, USA)
- Karnkowska, Anna (Warsaw, Poland)
- Ke, Hangjun (Philadelphia, PA, USA)
- Kita, Kiyoshi (Tokyo, Japan)
- Kunji, Edmund (Cambridge, United Kingdom)
- Lane, Nick (London, United Kingdom)
- Lang, Franz Bernd (Montréal, QB, Canada)
- Lavrov, Dennis V. (Ames, IA, USA)
- Lill, Roland (Marburg, Germany)
- Lukeš, Julius (Ceské Budejovice, Czech Republic)
- Metcalf, William W. (Urbana, IL, USA)
- Meyer, Etienne (Potsdam, Germany)
- Murphy, Michael P. (Cambridge, United Kingdom)
- Patel, Maulik (Nashville, TN, USA)
- Rand, David M. (Providence, RI, USA)
- Roger, Andrew J. (Halifax, NS, Canada)
- Roth, Mark B. (Seattle, WA, USA)
- Smith, David R. (London, ON, Canada)
- Stairs, Courtney (Uppsala, Sweden)
- Steyn, Adrie J.C. (Durban, South Africa)
- Storey, Kenneth B. (Ottawa, ON, Canada)
- Tachezy, Jan (Prague, Czech Republic)
- Takenaka, Mizuki (Ulm, Germany)
- Tarassov, Ivan (Strasbourg, France)
- Tsaousis, Anastasios (Canterbury, United Kingdom)
- Van der Giezen, Mark (Exeter, United Kingdom)
Chaired by David A. Keays (Vienna, Austria) and William R. Schafer (Cambridge, United Kingdom)
The ability to sense and respond to physical stimuli is critical to life. This conference will bring together leaders in the life and physical sciences and will discuss the biology that underpins three overlooked senses. How do animals detect magnetic fields? What molecules mediate the detection of hot and cold? And how is a mechanical stimulus transduced into a neuronal impulse?
The conference will include investigators employing advanced genetic tools in established model systems, but also explore alternative species that are well suited to addressing specific scientific problems. Guided by the behavioural repertoire of these animals, we will discuss the underlying biophysical mechanisms and molecules that underlie the detection of a particular stimulus. This will be complemented by a series of talks that exploit these insights to develop novel synthetic tools in neuroscience.
- Busserolles, Jérôme (Clermont-Ferrand, France)
- Caterina, Michael J. (Baltimore, MD, USA)
- Chatzigeorgiou, Marios (Bergen, Norway)
- Cybulski, Larisa Estefania ( Rosario, Santa Fe, Argentinia)
- Fedele, Giorgio (Leicester, United Kingdom)
- Göpfert, Martin (Göttingen, Germany)
- Gracheva, Elena (New Haven, CT, USA)
- Grandl, Jörg (Durham, NC, USA)
- Güler, Ali D. (Charlottesville, VA, USA)
- Hardie, Roger ( Cambridge, United Kingdom)
- Heyers, Dominik (Oldenburg, Gemany)
- Holt, Jeffrey (Boston, MA, USA)
- Hore, Peter J. (Oxford, United Kingdom)
- Hudspeth, A. James (New York, NY, USA)
- Kindt, Katie (Bethesda, MD, USA)
- Kirschvink, Joseph L. (Pasadena, CA, USA)
- Landler, Lukas (Blacksburg, VA, USA)
- Lewin, Gary R. (Berlin-Buch, Germany)
- Lohmann, Kenneth J. (Chapel Hill, NC, USA)
- Lumpkin, Ellen A. (New York, NY, USA)
- Marcotti, Walter (Sheffield, United Kingdom)
- Minor, Daniel L. (San Francisco, CA, USA)
- Montell, Craig (Santa Barbara, CA, USA)
- Mori, Yasuo (Kyoto, Japan)
- Mouritsen, Henrik Østergaard (Oldenburg, Germany)
- Mueller, Ulrich (San Diego, CA, USA)
- Muheim, Rachel (Lund, Sweden)
- Mulhull, Eric (Boston, MA, USA)
- Nemec, Pavel (Praha, Czech Republic)
- Nicolson, Teresa (Portland, OR, USA)
- Okabe, Kohki (Tokyo, Japan)
- Patapoutian, Ardem (La Jolla, CA, USA)
- Phillips, John B. (Blacksburg, VA, USA)
- Schüler, Dirk (Bayreuth, Germany)
- Sengupta, Piali (Waltham, MA, USA)
- Stanley, Sarah (New York, NY, USA)
- Steel, Karen (London, United Kingdom)
- Vermot, Julien (Ilkirch, France)
- Vidal-Gadea, Andrés G. (Normal, Illinois, USA)
- Voets, Thomas (Leuven, Belgium)
- Wood, John (London, United Kingdom)
- Xie, Can (Beijing, China)
Chaired by Jason N.D. Kerr (Bonn, Germany), Richard H.R. Hahnloser (Zurich, Switzerland) and Loren L. Looger (Ashburn, VA, USA)
Understanding how the components that make up the brain are used by the behaving animal to interact with its environment is a serious challenge. Over the past decade the number of tools that have become available to study the brain and animal behaviour has increased enormously and has transformed the types of questions that can be asked.
By bringing together a diverse group of interdisciplinary scientists involved in developing methods and applications for quantifying behaviour or measuring brain activity, the hope is to promote the exchange of ideas and approaches between different research fields.
- Beck, Heinz (Bonn, Germany)
- Brecht, Michael (Berlin, Germany)
- Buffalo, Elizabeth A. (Seattle, WA, USA)
- Dudman, Joshua T. (Ashburn, VA. USA)
- Fitzpatrick, David (Jupiter, FL, USA)
- Gan, Wenbiao (New York, NY, USA)
- Greenberg, David (Bonn, Germany)
- Grewe, Benjamin F. (Stanford, CA, USA)
- Gütig, Robert (Göttingen, Germany)
- Hanke, Wolf ( Rostock, Germany)
- Haydon Wallace, Damian James (Bonn, Germany)
- Jayaraman, Vivek (Ashburn, VA, USA)
- Laurent, Gilles (Frankfurt a.M., Germany)
- Lavis, Luke D. (Ashburne, VA, USA)
- Leonardo, Anthony (Ashburne, VA, USA)
- Macke, Jakob (Tübingen, Germany)
- Margrie, Troy (Londen, UK)
- Martin, Kevan A.C. (Zurich, Switzerland)
- Mehta, Mayank R. (Zurich, Switzerland)
- Mikula, Shawn (Heidelberg, Germany)
- Mouritsen, Henrik Østergaard ( Oldenburg, Germany)
- O'Keefe, John (London, UK)
- Ölveczky, Bence (Cambridge, MA, USA)
- Prescott, Tony J. (Sheffield, UK)
- Roberts, Todd (Dallas, TX, USA)
- Schuster, Stefan (Bayreuth, Germany)
- Schwartz, Andrew B. (Pittsburg, PA, USA)
- Silies, Marion (Göttingen, Germany)
- Tkacik, Gasper (Klosterneuburg, Austria)
- Ulanovsky, Nachum (Rehovot, Israel)
- Vaziri, Alipasha (Vienna, Austria)
- Wickens, Jeff (Oinawa, Japan)
- Wikelski, Martin C. (Radolfzell, Germany)
- Wolf, Fred (Göttingen, Germany)
- Zoccolan, Davide (Trieste, Italy)
Dates, chairs, and titles of further past ITCs
112th ITC, 21–25 October 2015
Jürgen A. Knoblich, Vienna, Austria; Hans Clevers, Utrecht, The Netherlands
"Organoids: modelling, development, and disease in 3D culture"
111th ITC, 15–19 April 2015
Luke O’Neill, Dublin, Ireland; Michael P. Murphy, Cambridge, United Kingdom; Erika L. Pearce, St. Louis, MO, USA
"Rediscovering Warburg – the role of metabolism in signalling disease"
110th ITC, 8–12 October 2014
Holger Stark, Göttingen, Germany; Matthias Rief, Garching, Germany
"Structure, forces, and dynamics of macromolecular complexes"
109th ITC, 9–13 April 2014
Dan R. Littman, New York, NY, USA; Samuel I. Miller, Seattle, WA, USA; Philippe J. Sansonetti, Paris, France
"Microbiome-host mutualism in the shaping of host immunity"
108th ITC, 23–27 October 2013
Angelika B. Amon, Cambridge, MA, USA; Don W. Cleveland, La Jolla, CA, USA
"Causes and consequences of aneuploidy"
107th ITC, 5–10 March 2013
Elena Conti, Martinsried, Germany; Anne Ephrussi, Heidelberg, Germany
106th ITC, 10–14 October 2012 – 50 years ITC
Andrea Mussachio, Dortmund, Germany; Tom Muir, New York, NY, USA
"Reconstituting chromatin: from self-assembly to self-organisation"
105th ITC, 28 March –1 April 2012
Kai L. Simons, Dresden, Germany; Gisou van der Goot, Lausanne, Switzerland
"Lipids as organisers of cell membranes"
104th ITC, 12–16 October 2011
Patrick Cramer, Munich, Germany
103rd ITC, 23–27 March 2011
Barry Dickson, Vienna, Austria
Genetic analysis of neural circuits
102nd ITC, 13–17 October 2010
Thomas Jentsch, Berlin, Germany; Gary Lewin, Berlin, Germany; Christine Petit, Paris, France
"Sensory transduction, the gateway to perception: mechanisms and pathology"
101st ITC, 17–21 March 2010
Jonathon Howard, Dresden, Germany; Julie Theriot, Stanford, CA, USA
"Mechanics of cells and tissues: sensing, generating, and coordinating forces in biological systems"
100th ITC, 14–18 October 2009
Axel Meyer, Konstanz, Germany; Yves Van de Peer, Ghent, Belgium
"Genome evolution and the origin of novel gene functions"
99th ITC, 25–29 March 2009
Bernd Bukau, Heidelberg, Germany; Stefan Jentsch, Martinsried, Germany
"Cellular safeguards and quality control"
98th ITC, 5–9 November 2008
Rudolf Jaenisch, Cambridge, MA, USA; Thomas Graf, Barcelona, Spain
"Differentiation, reprogramming, and regeneration"
97th ITC, 12–16 March 2008
Anne Ridley, London, United Kingdom; Matthias Peter, Zurich, Switzerland
"Mechanisms of cell polarity"
96th ITC, 14–18 November 2007
Stefan W. Hell, Göttingen, Germany; Jörg Enderlein, Jülich, Germany
"Trends in biological optical microscopy"
95th ITC, April 11–15 April 2007
Jan Hoeijmakers, Rotterdam, The Netherlands
"Molecular basis of aging"
94th ITC, 15–19 November 2006
Wolf Singer, Frankfurt, Germany
"The dynamical brain"
93rd ITC, 29 March–2 April 2006
U. Benjamin Kaupp, Jülich, Germany; Michael Eisenbach, Rehovot, Israel
"Mechanisms of chemotaxis"
92nd ITC, 19–23 October 2005
Meinrad Busslinger, Vienna, Austria
"Stem cells and haematopoietic tumors"
91st ITC, 6–10 April 2005
Hidde Ploegh, Boston, USA
"Cell biology meets the immune system: molecular aspects of host pathogens interactions"
90th ITC, 21–24 October 2004
Thomas Tuschl, New York, USA; Thomas Jenuwein, Vienna, Austria
89th ITC, 17–21 March 2004
Rudolf Valenta, Vienna, Austria; Thomas Brocker, Munich, Germany
"From allergy to cancer: new perspectives for therapeutic vaccination"
88th ITC, 22–26 October 2003
Jürgen Klingauf, Göttingen, Germany; Erwin Neher, Göttingen, Germany
"Synaptic transmission: from molecules to circuits"
87th ITC, 19–23 March 2003
Christian Haass, Munich, Germany; Roger Nitsch, Zurich, Switzerland
"Alzheimer's and Parkinson's disease: from basic science to therapeutic treatment"
86th ITC, 23–27 October 2002
Franz Xaver Schmid, Bayreuth, Germany; Reinhard Sterner, Cologne, Germany
"Protein design at the crossroad of biotechnology, chemistry, and evolution"
85th ITC, 13–17 March 2002
Sabine Werner, Zurich, Switzerland; Clive Dickson, London, Great Britain
"Growth factors in development, repair, and disease"
84th ITC, 24–28 October 2001
Alfred Wittinghofer, Dortmund, Germany; Alan Hall, London, Great Britain
"The actin cytoskeleton: from signalling to bacterial pathogenesis"
83rd ITC, 21–25 March 2001
Markus Hoth, Homburg, Germany; Veith Flockerzi, Homburg, Germany; Walther Stühmer, Göttingen, Germany
"Ion channels in health and disease"
82 ITC, 25–29 October 2000
Reinhard Jahn, Göttingen, Germany
81 ITC, 12–16 April 2000
Michael Reth, Freiburg, Germany; Lawrence E. Samelson, Bethesda, MD, USA
"Signal processing through protein complexes"
80th ITC, 4–7 November 1999
Kim Nasmyth, Vienna, Austria; Martin Raff, London, United Kingdom; Erwin Wagner, Vienna, Austria
"Growth control in cells, organs, and animals"
79th ITC, 28 April–2 May 1999
Peter Herrlich, Karlsruhe, Germany; Hartmut Land, London, United Kingdom
"Parallels in cancer and embryonic development"
78th ITC, 7–11 October 1998
Bernhard Horsthemke, Essen, Germany
"Molecular mechanisms in human malformation syndromes"
77th ITC, 4–8 March1998
Wolf Singer, Frankfurt, Germany; Christoph von der Malsburg, Bochum, Germany
"The role of timing in neuronal processing"
76th ITC, 15–19 October 1997
Cord Michael Becker, Erlangen, Germany; Adriano Aguzzi, Zurich, Switzerland
"Neurological disease: models, molecules, and mechanisms"
75th ITC, 5–9 March 1997
Christiane Nuesslein-Volhard, Tübingen, Germany; Eric Wieschaus, Princeton, NJ, USA
"Gradients in development – formation and interpretation"
74th ITC, 2–6 October 1996
Werner Franke, Heidelberg, Germany; Rolf Kemler, Freiburg, Germany
"Cell junctions and disease"
73rd ITC, 27–31 March 1996
Gert Riethmüller, Munich, Germany
"Dormant cancer and latent infection: novel strategies for immune intervention"
72nd ITC, 1–5 November 1995
Norbert E. Fusenig, Heidelberg, Germany; Petra Boukamp, Heidelberg, Germany
"Tumor angiogenesis and anti–angiogenesis: a major aspect in tumor–stroma interaction"
71st ITC, 22–26 March 1995
U. Benjamin Kaupp, Jülich, Germany; G.H. Gold, Philadelphia, PA, USA
"Signal transduction in vision and the chemical senses"
70th ITC, 5–9 October 1994
Fritz Melchers, Basel, Switzerland
69th ITC, 9–13 March 1994
Hinrich Rahmann, Stuttgart, Germany
"The neurobiology of memory formation in vertebrates: neuronal plasticity and brain function"
68th ITC, 27–31 October 1993
Michael Schramm, Jerusalem, Israel; Heinrich Betz, Frankfurt, Germany
"Open problems in brain glutamate receptors: structure, function, and neurotoxicity"
67th ITC, 17–21 March 1993
Anna Starzinski-Powitz, Cologne, Germany; Don Fishman, New York, USA
"Molecular and cellular biology of muscle development: in vivo analysis"
66th ITC, 4–8 November 1992
Wolfram Ostertag, Hamburg, Germany
"Somatic gene therapy – gene transfer and differentiation"
65th ITC, 4–8 March 1992
Sergej Fedoroff, Saskatoon, Canada; Georg W. Kreutzberg, Martinsried, Germany
"Neuroimmune networks: cell–cell communication and response to injury and regeneration in the CNS"
64th ITC, 16–20 October 1991
John G. Nicholls, Basel, Switzerland; Eric Shooter, Stanford, CA, USA
"Development, regeneration, and plasticity of the nervous system"
63rd ITC, 6–10 March 1991
Georg Wick, Innsbruck, Vienna
62nd ITC, 9–13 May 1990
Guenter Pasternak, Berlin-Buch, Germany
"Monoclonal antibodies in cancer research and diagnostic"
61st ITC, 28 March–1 April 1990
Gerd Heusch, Essen, Germany
"Adrenergic mechanisms in myocardial ischemia"
60th ITC, 14–18 February 1990
Benno Hess, Dortmund, Germany
"Deterministic chaos in biology and medicine"
59th ITC, 12–16 April 1989
G.A. Robison, Houston, TX, USA
"Drug action at the molecular level: differences between agonists and antagonists"
58th ITC, 1–5 March 1989
Gerald and Heide Schatten, Madison, WI, USA
"Nuclear cytoskeletal interactions"
57th ITC, 5–9 October 1988
Gerd Hunsmann, Göttingen, Germany
56th ITC, 11–15 May 1988
Rolf Knippers, Konstanz, Germany; A.J. Levine, Princeton, NJ, USA
"Transforming proteins of DNA tumor viruses"
55th ITC, 2–6 March 1988
Ludwig Heilmeyer, Bochum, Germany
"Signal transduction and protein phosphorylation"
54th ITC, 30 September–4 October 1987
Harald zur Hausen, Heidelberg, Germany
"Papillomavirus in human genital cancer: causative role and practical consequences"
53rd ITC, 13–17 May 1987
Hans Neurath, Seattle, WA, USA; E. Davie, Seattle, WA, USA; Fritz Melchers, Basel, Switzerland
"Proteolytic processing and biological function"
52nd ITC, 8–11 October 1986
Bernd Hamprecht, Tübingen, Germany; Dennis Monard, Basel, Switzerland
"Molecular factors involved in the development of the nervous system"
51st ITC, 23–27 April 1986
Bob Williamson, London, United Kingdom
"Human gene mapping and molecular pathology"
50th ITC, 2–6 October 1985
Werner Kalow, Toronto, Canada; Werner Goedde, Hamburg, Germany
"Ethnic differences in reactions to drugs and other xenobiotics"
49th ITC, 2–4 May 1985
George Weber, Indianapolis, IN, USA
48th ITC, 17–21 October 1984
Paul Gerhard Spieckermann, Göttingen, Germany; Hans-Michael Piper, Göttingen, Germany
"Isolated adult heart muscle cells, a new model for studies on cardiac metabolism, functions, and structure"
47th ITC, 10–14 October 1984
Alfred P. Fishman, Philadelphia, PA, USA
46th ITC, 5–9 October 1983
Sydney Brenner, Cambridge, United Kingdom
"Impact of modern molecular genetics on human biology and medicine"
45th ITC, 17–19 March 1983
Wolfgang Kübler, Heidelberg, Germany; A. Katz, Farmington, CT, USA
"Myocardial ischemia: pathogenesis, mechanisms and clinical implications"
44th ITC, 20–24 October 1982
Dennis Chapman, London, United Kingdom
"Trigger processes and biological membranes"
43rd ITC, 15–17 October 1982
Sabine von Kleist, Freiburg, Germany
"Transformation of the cell"
42nd ITC, 6–8 October 1982
Ernst Schöpf, Freiburg, Germany
"Meditors of allergy and inflammation"
41st ITC, 15–17 October 1981
Leo Sachs, Jerusalem, Israel
"Concepts in development and malignancy"
40th ITC, 1–3 October 1981
Michael Schramm, Jerusalem, Israel
"Fusion and implantation in biological membranes"
39th ITC, 2–4 October 1980
Helmut Holzer, Freiburg, Germany
"Metabolic interconversion of enzymes"
38th ITC, 6–9 March 1980
W. Loewenstein, Miami, FL, USA
"Structure and dynamics of membrane channels"
37th ITC, 18–20 October 1979
G.A. Robison, Houston, TX, USA
“Drug action at the molecular level: differences between agonists and antagonists”
36th ITC, 10–12 May 1979
Hans Dierck Waller, Tübingen, Germany
“Critical issues of bone marrow transplantation”
35th ITC, 26–28 October 1978
J.M. van Rossum, Nijmege, Netherlands; Fred Koss, Biberach, Germany
"Pharmacokinetics during drug development: data analysis and evaluation techniques"
34th ITC, 19–21 October 1978
Heinrich Matthys, Freiburg, Germany
“Biomedical engineering and data processing in pneumonology”
33rd ITC, 6–8 April 1978
Leo Sachs, Rehovot, Israel
“The genetic control of cell differentiation and malignancy”
32nd ITC, 13–15 October 1977
A.G. Motulsky, Seattle, WA, USA
“Human genetic variation in response to medical and environmental agents: pharmacogenetics and ecogenetics”
31st ITC, 30 March–2 April 1977
Max Burger, Basel, Switzerland
“Receptors: signal transmission”
30th ITC, 14–16 October 1976
Alfred P. Fishman, Philadelphia, PA, USA
“Non-respiratory functions of the lung in health and disease”
29th ITC, 25–27 March 1976
N.D. Goldberg, Minneapolis, MI, USA
“Cyclic nucleotides as regulators of proliferation and differentiated cell function”
28th ITC, April 24–27 April 1975
W.R. Loewenstein, Miami, FL, USA
“Information transfer between cells”
27th ITC, 6–8 March 1975
P. Harris, London, United Kingdom
“Perfusion of the lung”
26th ITC, 28–30 March 1974
Walter Kukovetz, Graz, Austria
“Cyclic AMP and membranes”
25th ITC, 21–23 March 1974
L.L.M. van Deenen, Utrecht, The Netherlands
“Dynamic of membranes”
24th ITC, 15–27 October 1973
Gustav V.R. Born, Cambridge, United Kingdom; Rudolf Gross, Köln, Germany
“Platelets in thrombosis: their clinical significance and the evaluation of potential drugs”
23rd ITC, 22–24 March 1973
Donald F. Hoelzl-Wallach, Boston, MA, USA
“Membrane aspects of neoplasia”
22nd ITC, 13–15 April 1972
Friedrich Vogel, Heidelberg, Germany
21st ITC, 23–25 March 1972
Franz Gross, Heidelberg, Germany; P. Wolff, Mainz, Germany
“Physiology and pathology of vascular response”
20th ITC, 28–30 October 1971
Dennis Chapman, Sheffield, United Kingdom
“Recent physical studies of the structure of biomembranes”
19th ITC, 30–31 October 1970
Dietrich W. Lübbers, Dortmund, Germany
“Problems of muscular circulation”
18th ITC, 13–14 March 1970
Hans Werner Goedde, Hamburg, Germany; Georg-Wilhelm Löhr, Freiburg, Germany; Hans-Dierck Waller, Tübingen, Germany
17th ITC, 6–7 March 1970
Werner Kaufmann, Tübingen, Germany; Hans-Erhard Bock, Tübingen, Germany
“Renin-angiotensin-aldosteron system and the influence of drugs”
16th ITC, 31 October–1 November 1969
Paul Schölmerich, Mainz, Germany; G. Gerlach, Aachen, Germany
“Arrest, survival time, and reanimation of the heart”
15th ITC, 24–25 October 1969
W. Kalkoff, Freiburg, Germany
14th ITC, 5–6 April 1968
Ernst Lüthy, Zürich, Switzerland
“Hypertrophy and hyperplasia in the heart”
13th ITC, 29–30 March 1968
Fred Lembeck, Tübingen, Germany; Rudolf Gross, Köln, Germany
“Problems in general clinical pharmacology”
12th ITC, 26–28 October 1967
H. Hassler, Frankfurt/Main, Germany
11th ITC, 21–22 April 1967
Hans-Erhard Bock, Tübingen, Germany
“Problems of reno-vascular hypertension”
10th ITC, 14–15 April 1967
Herbert Braunsteiner, Innsbruck, Austria
"Clinical problems of transplantation immunology”
9th ITC, 28–29 October 1966
Rudolf Gross, Köln, Germany
“Problems of modern diagnosis”
8th ITC, 25–26 March 1966
R. Bing, Detrois, MI, USA
“Myocardial insufficiency – clinical and experimental correlations”
7th ITC, 28–30 October 1965
F. Grosse-Brockhoff, Düsseldorf, Germany
“Cardiac metabolism under different physiological, pharmacological, and pathological conditions”
6th ITC, 26–27 March 1965
Hans-Erhard Bock, Tübingen, Germany
“On the situation of clinical therapeutical research”
5th ITC, 30–31 October 1965
E. Brücke, Vienna, Austria
“Physiological and clinical aspects of myocardial stimulus origin and stimulus propagation”
4th ITC, 13–14 March 1964
Helmut Baitsch, Freiburg, Germany; Hans Werner Goedde, Freiburg, Germany
“Pharmacogenetics – results and problems”
3rd ITC, 25–26 October 1963
Albrecht Fleckenstein, Freiburg, Germany
“Excitation, contractility, and metabolism of the myocardium”
2nd ITC, 30–31 March 1963
Erich Letterer, Tübingen, Germany
“Dynamics, morphology, and biochemistry of inflammation”
1st ITC, autumn 1962
Ludwig Heilmeyer, Freiburg, Germany; E.H. Fischer, Seattle, WA, USA
“On the pathophysiology of insufficient cardiac circulation, its significance for heart functions and possibilities for its treatment”