SciencePersistent viruses need persistent researchersInterview with Harald zur Hausen, former director of the German Cancer Research Center (DKFZ), Heidelberg, Germany Harald zur Hausen proved that the infection with particular papillomaviruses causes cervical cancer, which kills some 250,000 women worldwide each year. In this interview he outlines the stony path from the initial research results to a vaccine that protects from cervical cancer and describes future vaccination approaches. Citation: (2007) Persistent viruses need persistens researchers. Interview with Harald zur Hausen. B.I.F. FUTURA 22(4), 214-217 Copyright: © Boehringer Ingelheim Fonds. This is an open-access article distributed under the terms of the “Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities”, which permits free, irrevocable and universal right on access to these contributions and allow the work to be used, reproduced, or disseminated in digital form, provided the original author, copyright holder and source are credited.  Download PDF of the article (112 KB)
Epistemology. What happened to molecular biology?Hans-Jörg Rheinberger Department III, Max Planck Institute for the History of Science, Berlin, Germany Molecular biology emerged in the first half of the 20th century as a fundamentally novel type of biology. Hans-Jörg Rheinberger, historian of science, describes its development and dissolution as a discipline in its own right. Citation: (2007) Epistemology. What happened to molecular biology? B.I.F. FUTURA 22(4), 218-223 Copyright: © Hans-Jörg Rheinberger. This is an open-access article distributed under the terms of the “Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities”, which permits free, irrevocable and universal right on access to these contributions and allow the work to be used, reproduced, or disseminated in digital form, provided the original author, copyright holder and source are credited. Download PDF of the article (296 KB)
Reviews
Molecular biology of the 21st century. From molecules to systems – a quantum jump in complexity
Ernst J.M. Helmreich 1, Rainer Jaenicke 21 University of Würzburg, Würzburg, Germany 2 University of Regensburg, Regensburg, Germany The German Academy of Sciences Leopoldina had invited a broad spectrum of international scientists to discuss the state of molecular biology and the impact of the “new” biology on biomedical research. Citation: Helmreich, EJM et al. (2007) Molecular biology of the 21st century. From molecules to systems – a quantum jump in complexity. B.I.F. FUTURA 22(4), 207-213 Copyright: © Ernst J.M. Helmreich et al. This is an open-access article distributed under the terms of the “Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities”, which permits free, irrevocable and universal right on access to these contributions and allow the work to be used, reproduced, or disseminated in digital form, provided the original author, copyright holder and source are credited. Download PDF of the article (336 KB)
Research Articles of B.I.F. Fellows (Results)In these final accounts, B.I.F. scholarship holders present a brief summary of the research results and publications of their PhD project. Drosophila Mud regulates spindle orientation in asymmetric cell divisionSarah Bowman Research Group Jürgen Knoblich, Institute of Molecular Biotechnology (IMB), Vienna, Austria Negative selection of thymocytes requires PKC- and Ca2+-mediated Bim transcriptionKirsten Canté-Barrett Laboratory of Gerald R. Crabtree, Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, CA, USA The AAA-ATPase p97 is dispensable for spindle disassembly at mitotic exitSimone Heubes Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany A compass without a needle: chemotaxis in the absence of polarized PtIns(3,4,5)P3 signallingOliver Hoeller Division of Cell Biology, MRC-Laboratory of Molecular Biology, Cambridge, UK Coloured approach to study the phagosome biogenesis of intracellular pathogensChristoph Lippuner Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany Analysis of CTRP, a Plasmodium ookinete surface proteinChandra Ramakrishnan Division of Cell and Molecular Biology, Imperial College London, London, UK Photoactivated processes in biomolecules studied by molecular dynamics simulationsLars Schäfer Department of Theoretical and Computational Biophysics, Max Planck Institute of Biophysical Chemistry, Göttingen, Germany Studies on plant Rho activation lead to a universal model of GEF catalysisChristoph Thomas Department of Structural Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany Regulation of endocytic traffic by membrane phosphoinositidesRoberto Zoncu School of Medicine, Yale University, New Haven, CT, USA Download Research Articles (1,4 MB)Copyright: © These are open-access articles distributed under the terms of the “Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities”, which permits free, irrevocable and universal right on access to these contributions and allow the work to be used, reproduced, or disseminated in digital form, provided the original author, copyright holder and source are credited.
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Typical set-up for molecular dynamics (MD) simulations: the biomolecule (spheres) is solvated with water (wire-frame representation). MD simulations yield the dynamics of molecules with a femtosecond (10-15 s) time resolution and with atomic resolution. For further details, see the article by Lars Schäfer.
Copyright: © Boehringer Ingelheim Fonds
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